Кроме последовательности аминокислот полипептида (первичной структуры), крайне важна третичная структура белка, которая формируется в процессе фолдинга (от англ. folding, «сворачивание»). Третичная структура формируется в результате взаимодействия структур более низких уровней. Выделяют четыре уровня структуры белка (см. рисунок 1).
Рисунок 1 – Уровни структур белка
Первичная структура – последовательность аминокислот в полипептидной цепи. Важными особенностями первичной структуры являются консервативные мотивы – сочетания аминокислот, играющих ключевую роль в функциях белка. Консервативные мотивы сохраняются в процессе эволюции видов, по ним часто удаётся предсказать функцию неизвестного белка.
Первичная структура – число и последовательность аминокислот, соединенных друг с другом пептидными связями в полипептидной цепи
Вторичная структура – локальное упорядочивание фрагмента полипептидной цепи, стабилизированное водородными связями. Ниже приведены самые распространённые типы вторичной структуры белков:
– α-спирали – плотные витки вокруг длинной оси молекулы, один виток составляют 3,6 аминокислотных остатка, и шаг спирали составляет 0,54 нм (так что на один аминокислотный остаток приходится 0,15 нм), спираль стабилизирована водородными связями между H и O пептидных групп, отстоящих друг от друга на 4 звена. Спираль построена исключительно из одного типа стереоизомеров аминокислот (L). Хотя она может быть как левозакрученной, так и правозакрученной, в белках преобладает правозакрученная. Спираль нарушают электростатические взаимодействия глутаминовой кислоты, лизина, аргинина. Расположенные близко друг к другу остатки аспарагина, серина, треонина и лейцина могут стерически мешать образованию спирали, остатки пролина вызывает изгиб цепи и также нарушает α-спирали;
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– β-листы (складчатые слои) – несколько зигзагообразных полипептидных цепей, в которых водородные связи образуются между относительно удалёнными друг от друга (0,347 нм на аминокислотный остаток) в первичной структуре аминокислотами или разными цепями белка, а не близко расположенными, как имеет место в α-спирали. Эти цепи обычно направлены N-концами в противоположные стороны (антипараллельная ориентация). Для образования β-листов важны небольшие размеры боковых групп аминокислот, преобладают обычно глицин и аланин;
– π-спирали;
– 310-спирали;
– неупорядоченные фрагменты.
Для всякого белка характерна помимо первичной еще и определенная вторичная структура. Обычно белковая молекула напоминает растянутую пружину.
Третичная структура – пространственное строение полипептидной цепи (набор пространственных координат составляющих белок атомов). Структурно состоит из элементов вторичной структуры, стабилизированных различными типами взаимодействий, в которых гидрофобные взаимодействия играют важнейшую роль. В стабилизации третичной структуры принимают участие:
– ковалентные связи (между двумя остатками цистеина – дисульфидные мостики);
– ионные связи между противоположно заряженными боковыми группами аминокислотных остатков;
– водородные связи;
– гидрофильно-гидрофобные взаимодействия. При взаимодействии с окружающими молекулами воды белковая молекула «стремится» свернуться так, чтобы неполярные боковые группы аминокислот оказались изолированы от водного раствора; на поверхности молекулы оказываются полярные гидрофильные боковые группы.
Полипептидные цепи свернуты особым образом в компактную глобулу. Способ свертывания полипептидных цепей глобулярных белков называется третичной структурой.
Четвертичная структура (или субъединичная, доменная) – взаимное расположение нескольких полипептидных цепей в составе единого белкового комплекса. Белковые молекулы, входящие в состав белка с четвертичной структурой, образуются на рибосомах по отдельности и лишь после окончания синтеза образуют общую надмолекулярную структуру. В состав белка с четвертичной структурой могут входить как идентичные, так и различающиеся полипептидные цепочки. В стабилизации четвертичной структуры принимают участие те же типы взаимодействий, что и в стабилизации третичной. Надмолекулярные белковые комплексы могут состоять из десятков молекул. Многие белки с особо сложным строением состоят из нескольких полипептидных цепей. Способ совместной упаковки и укладки этих полипептидных цепей называют четвертичной структурой белка.